Retinal Nerve Fiber Layer and Central Corneal Thickness in Patients with Exfoliation Syndrome

Purpose: To evaluate the retinal nerve fiber layer (RNFL) and central corneal thickness (CCT) in patients with exfoliation syndrome (XFS) Methods: In this comparative case series we measured RNFL thickness and CCT in 30 patients with XFS and in 30 age and sex matched healthy subjects who met the inclusion criteria. Results: Average RNFL in XFS group were significantly thinner than controls (94.36±8.70 μm vs. 100.80±6.68 μm) (P=0.002). In the analysis with regard to quadrants, no statistically significant reduction in RNFL thickness was found between groups. XFS patients and controls did not differ in CCT measurements (522.90±40.71 μm vs. 517.30±30.50 μm) (P=0.549). Conclusion: No significant differences in CCT and RNFL thickness in temporal, nasal, superior and inferior quadrants between XFS and controls were observed. However, average RNFL measurements in eyes with XFS showed lower values.